James O’Neill has worked with Charles River since 2012 and is currently Director of Chemistry at our Edinburgh site.
He is responsible for about 55 scientists working towards the quantitation and identification of metabolites and degradants in metabolism, metabolomic, e-fate, and field and veterinary residues studies in support of pharmaceutical, agrochemical, and animal health product development.
James has a PhD in Chemistry and a Master’s Degree in Chemistry with Pharmaceutical Chemistry, both from Heriot-Watt University in Edinburgh. He was once an intern with Charles River and spent time with Dr. Ai-Lan Lee working on the chiral synthesis of supramolecular molecules and gold (III) catalysis.
Publications
Future of Biotransformation Science in the Pharmaceutical Industry
Valerie M. Kramlinger, Deepak Dalvie, Carley JS Heck, Amit S. Kalgutkar, James O'Neill, Dian Su, Aaron Teitelbaum and Rheem A. Totah
Drug Metabolism and Disposition December 17, 2021, DMD-MR-2021-000658; DOI: https://doi.org/10.1124/dmd.121.000658
“Synthesis of a C1-Symmetric Box Macrocycle and Studies toward Active Template Synthesis of Mechanically Planar Chiral Rotaxanes”, P. E. Glen, J. A. T. O’Neill, A.-L. Lee, Tetrahedron, 2013, 67, 57-68
Gold(III)-oxo complexes as catalysts in intramolecular hydroamination”, J. A. T. O’Neill, G. M. Rosair, A.-L. Lee, Catal. Sci. Technol., 2012, 2, 1818-1821
“Computational Studies on the Mechanism of the Gold(I)-Catalysed Rearrangement of Cyclopropenes”, M. S. Hadfield, L. J. Häller, A.-L. Lee, S. A. Macgregor, J. A. T. O’Neill, A. M. Watson, Org. Biomol. Chem., 2012, 10, 4433-4440.