Advancing Cell Therapy Technologies for Manufacturing

As part of our commitment to making cell and gene therapy manufacturing more predictable, efficient, and scalable, we are continually researching and testing cutting-edge cell therapy technologies. By integrating process optimization, automation with closed-system processing, and modular manufacturing strategies, we help clients improve batches and accelerate production timelines.

Talk to Our Team

Charles River CDMO manufacturers cell and gene therapies using cell therapy technologies

Explore our resource hub below on topics such as streamlining cell therapy manufacturing workflows, gene editing innovations, scaling fill-finish, and more.

Featured Resource

Integrating Microbubbles into a CAR-T Workflow

Leveraging advancements in cell separation, this webinar shares innovations in CAR-T workflows using GMP-ready microbubbles.

Download Now

CAR-T cell therapy with white and red cells.

Cryopreservation Methods for CAR-T Cells

Discover how different cryopreservation methods impact CAR-T cells when it comes to phenotype and function.

Explore the findings

Cryopreservation methods explored include the Cryocase, cryobags, and vials.
Laboratory vials in a plastic rack that help with automated fill and finish

The Future of Fill and Finish

Delve into a new era of automated fill and finish with this whitepaper that addresses risks with contaminants and consistency in batches.

Get the Insights

Making Gains in Non-viral Engineering of T Cells for Cell Manufacturing

In this study, we evaluated three leading electroporation platforms: Kytopen's Flowfect Tx and two blinded competitors to assess cell counts, flow cytometry, and potency.

Download the findings

Charles River scientist working in a cell manufacturing lab.
Scientific poster on automated and scalable fill-finish process.

Closed Automation Enables Quick Fill-Finish Poster

Find out how to maintain quality, consistency, and reduce risk during the critical step of fill-finish as well as scale T cell therapies.

Download the Poster

Scaling CAR T Manufacturing with Automated Fill-Finish

Learn how to redefine large volume fill and finish with an automated solution that integrates multiple functionalities from formulation to filling drug product containers.

Download the Poster

Scientific poster on large-volume fill and finish.

Achieving Consistency in Fill Finish for Cell Therapies

Learn how you can achieve consistency and reduce risks to ensure scale-out strategies for multiple bag requirements and post-thaw viability in a closed environment.

Watch Webinar

Charles River scientist using Fill and finish capabilities that scale cell therapy drug product.
Charles River scientist working with cryopreservation methods and a novel cryo container.

Comparing CAR T Cells Across Novel Cryopreservation Containers and Platforms

Learn more about current methods for cryopreservation processes and a novel container that is both more robust and adaptable for these potentially lifesaving cells.

Watch Now

Successfully Scale T Cell Products with the FINIA® Fill and Finish System

As the development of cell therapies continues to grow, demonstrating that this automated, scalable approach to fill finish can maintain product uniformity and quality is crucial.

Read the Story

Vial with pink liquid
Charles River lab employee working with advanced cell therapy technologies, which are needed to enhance cell viability in gene-modified cell therapies.

Non-viral Engineering of T Cells

This 10-day study was performed using the same two donors with each platform. Cell viability, cell density, knockout efficiency, negative viable cells, and fold expansion were all measured.

Read More

Innovating Cell Therapy Manufacturing

Our work with Ori Biotech is part of a larger commitment to improve and scale advanced therapies to meet the growing patient demand for life-saving therapies.

Read More

Charles River cell and gene CDMO scientists research and test the latest cell therapy technologies and platforms in CGT manufacturing.
Charles River scientist working on the Integration of GMP cytokines into the Flex Platform, which streamlines operations, minimizes risk, and improves process robustness.

Akron Bio

Explore how closed system automation is transforming cell therapy manufacturing by boosting efficiency, reducing risk, and accelerating delivery.

Read More