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ChanTest Cell Lines

Charles River scientists have pioneered ion channel research for nearly 20 years, creating more than 120 functionally validated assays and cell lines. This industry-leading expertise, combined with our wide array of technologies for screening, profiling, and mechanism of action (MOA) studies, makes us unmatched in our ability to support our partners’ quests for the discovery of novel ion channel therapeutics.

ion channel testing

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Category

  • GPCRs (143)
  • Ion Channel (145)
  • Other (1)

Family

  • Acid-Sensing (3)
  • Calcium, Voltage-Gated (15)
  • Chloride (4)
  • Hyperpolarization-Gated (5)
  • Ligand-Gated (37)
  • Potassium, Calcium-Activated (5)
  • Potassium, Inward Rectifier (6)
  • Potassium, Two-Pore Leak (1)
  • Potassium, Voltage-Gated (25)
  • Sodium, Epithelial (2)
  • Sodium, Voltage-Gated (15)
  • TRP (21)

Product Type

  • EZ Cells™ DA (51)
  • EZ Cells™ TT (33)
  • Membrane (38)
  • Replicating Cell Line (168)

Receptor

  • Acetylcholine (6)
  • Adenosine (3)
  • Adrenergic (11)
  • Angiotensin (1)
  • Bombesin (2)
  • Cannabinoid (12)
  • CGRP (1)
  • Chemokine (1)
  • Cholecystokinin (4)
  • Endothelin (4)
  • Formylpeptide (3)
  • Free Fatty Acid (9)
  • Galanin (1)
  • Gastric Inhibitory Polypeptide (2)
  • Gastrointestinal Peptide (1)
  • Glutamate (4)
  • Histamine (2)
  • Lysophosphatidic Acid (3)
  • Lysophospholipid (2)
  • Mas-Related (2)
  • Melanocortin (1)
  • Mrg-X2 (1)
  • Muscarinic (13)
  • N-Formyl Peptide (1)
  • Neurotensin (1)
  • Nicotinic (4)
  • Nicotinic Acetylcholine (1)
  • Opioid (8)
  • Orexin (5)
  • Oxytocin (2)
  • Prokineticin (2)
  • Protease-Activated (5)
  • Purinergic (16)
  • Relaxin (3)
  • RFamide Peptide (2)
  • Serotonin (12)
  • Somatostatin (4)
  • Thromboxane (6)
  • Vanilloid (2)
  • Vasopressin (7)

Recommended Assay

  • Calcium (73)
  • CAMP (39)
  • FlexStation III (16)
  • FLIPR® (56)
  • IonWorks Barracuda™ (13)
  • IonWorks Quattro™ (25)
  • PatchXpress® (46)
  • QPatch HT (41)

Target Type

  • GPCR (144)
  • Ion Channel (143)

Therapeutic Area

  • Cancer (59)
  • Cardiac (53)
  • Genitourinary (21)
  • Metabolic & Gastrointestinal (64)
  • Neurodegeneration & Stroke (59)
  • Nonspecific (16)
  • Pain & Inflammation (113)
  • Psychiatric Disorder (49)
  • Pulmonary-Respiratory (41)
  • Seizure-Convulsion (48)
  • Vascular (60)

Human 5-HT1A Serotonin Receptor Cell Line

Human 5-HT1A Serotonin Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line.

Catalog Number

A601

Human 5-HT1A Serotonin Receptor Membranes

Frozen membranes from CHO-K1 cells expressing recombinant human 5-HT1A Serotonin receptors.

Catalog Number

A301

Human 5-HT2B Serotonin Receptor Cell Line

Human Serotonin 5-HT2B Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line.

Catalog Number

A659

Human 5-HT2B Serotonin Receptor EZCells™ DA

Human 5-HT2B Serotonin Receptor-expressing GPCR (G protein-coupled receptor) division-arrested cells.

Catalog Number

A459

Human 5-HT2C Serotonin Receptor Cell Line

Human 5-HT2C Serotonin Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line.

Catalog Number

A661

Human 5-HT2C Serotonin Receptor Membranes

Frozen membranes from CHO-K1 cells expressing recombinant human 5-HT2C Serotonin receptors.

Catalog Number

A161

Human 5-HT3A Serotonin Receptor Cell Line

Human 5-HT3A Serotonin Receptor-expressing, stable replicating cell line.

Catalog Number

CTN6117

Human 5-HT3A Serotonin Receptor EZCells™ TT

Human 5-HT3A Serotonin Receptor-expressing, transiently transfected cells

Catalog Number

CTN7117

Human 5-HT6 Serotonin Receptor Cell Line

Human 5-HT6 Serotonin Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line.

Catalog Number

A605

Human A1 Adenosine Receptor Cell Line

Human Adenosine A1 Receptor-expressing GPCR (G protein-coupled receptor) stable, replicating cell line.

Catalog Number

A683

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