Featured News
Innovative CNV Models in Large Animals
Presented at ARVO 2025
In a recent ARVO 2025 session, our Ocular Toxicology experts, Shivakumar Vasanth and Mark Vézina presented results from a novel alternate CNV model developed in a large animal. This approach offers significant advantages, including a higher number of clinically relevant lesions with fluorescein leakage compared to traditional slit-lamp laser methods.
Revolutionizing Ocular Therapeutics with CNV Breakthroughs
In the fight against vision loss, every moment matters. That’s why we continue to advance preclinical tools that help bring new therapies to patients faster. For decades, we’ve been a trusted leader in ocular research, offering validated choroidal neovascularization (CNV) models to support drug development for wet age-related macular degeneration (wet AMD)—a leading cause of irreversible blindness in older adults. Our laser-induced CNV model replicates the pathological blood vessel growth and leakage seen in wet AMD, enabling precise therapeutic evaluation.
New CNV Model Offers Clinically Relevant Advantages
The new alternate CNV model, developed at our Mattawan site, uses an endo-laser probe inspired by human photocoagulation techniques. This method delivers a 532 nm laser to six retinal spots per eye, creating larger lesions than traditional slit-lamp lasers, with about 95% success in inducing neovascular leakage patterns similar to wet AMD.
Advancing Research Through Alternative Approaches
While differing from conventional models, this alternate choroidal neovascularization approach opens new avenues to study disease progression and treatment response in a more clinically relevant setting.
Let’s Advance Wet AMD Research Together
Exploring novel wet AMD therapies or optimizing your CNV model selection? Partner with us to access a full range of ocular research innovations. Our expert team is dedicated to pioneering alternate CNV models and delivering tailored solutions that accelerate your drug development journey.
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