LVG Golden Syrian Hamster Details
The Golden Syrian Hamster is applicable for studies relating to SARS-CoV-2 due to its high levels of sequence homology with human ACE2 receptors and strong viral titers within 48 hours of inoculation. The model exhibits maximum clinical signs such as high lung viral load, cytokine activation, spleen and lymphoid atrophy, and can develop serum antibodies.
Three members of a litter captured in Syria in 1930 were retained in captivity. It is the progeny of these golden hamsters that were first imported to the United States in 1938. Descended from two original colonies acquired by Lakeview in 1949 and 1951. Closed outbred colony since 1951. To Charles River in 1969.
LOCATION: Kingston
UNIT: K62
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Try out this model with our animal evaluation program (North America)
LVG Golden Syrian Hamster Details
The Golden Syrian Hamster is applicable for studies relating to SARS-CoV-2 due to its high levels of sequence homology with human ACE2 receptors and strong viral titers within 48 hours of inoculation. The model exhibits maximum clinical signs such as high lung viral load, cytokine activation, spleen and lymphoid atrophy, and can develop serum antibodies.
Three members of a litter captured in Syria in 1930 were retained in captivity. It is the progeny of these golden hamsters that were first imported to the United States in 1938. Descended from two original colonies acquired by Lakeview in 1949 and 1951. Closed outbred colony since 1951. To Charles River in 1969.
Please email us at [email protected] to request a health report for this model.
For additional information, including pricing details, please visit the LVG Golden Syrian hamster page on the Vital River Laboratories website.
Try out this model with our animal evaluation program (North America)
Experimental Antiviral for COVID-19 Effective in Hamster Study
MK-4482 shows potential to prevent and treat SARS-CoV-2 infection. A new study from National Institutes of Health (NIH) scientists showed decreased levels of virus and disease damage in lungs of hamsters treated for SARS-CoV-2.
COVID-19 Biology: Influence of the Golden Hamster
This webinar will share the research conducted by our guest presenter to understand the host response to SARS-CoV-2 with a small range of animal models. We’ll also cover why the Golden Hamster is an ideal model to study viral transmission and pathology, and how it can effectively screen antivirals.
Resources
- Control Data
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Publications
- Fatal COVID-19 Pulmonary Disease Involves Ferroptosis
- Animal Models and Vaccines for SARS-CoV Infection
- Is There an Ideal Animal Model for SARS?
- Attenuated SARS-CoV-2 Variants with Deletions at the S1/S2 Junction
- Pathogenesis and Transmission of SARS-CoV-2 Virus in Golden Syrian Hamsters
- Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility
- Rapid Isolation of Potent SARS-CoV-2 Neutralizing Antibodies and Protection in a Small Animal Model
- Syrian Hamster as an Animal Model for the Study on Infectious Diseases
- Mice, Hamsters, Ferrets, Monkeys. Which Lab Animals Can Help Defeat the New Coronavirus?
- Coronavirus: Hamsters May Show Path Toward Reducing Viral Load in Covid-19 Patients, Hong Kong Microbiology Team Finds
- Hamsters as Model of Severe Acute Respiratory Syndrome Coronavirus-2
- Eureka Blog
Frequently Asked Questions About the Golden Syrian Hamster
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How are Golden Syrian Hamsters used in SARS-CoV2 research?
The LVG Golden Syrian Hamster supports growth of SARS-CoV-2 with robust viral titers within 48 hours of inoculation. Ease of handling, natural infection, and efficient transmission make this an ideal research model for your COVID-19 studies. Applications:
- Investigation of pathogenesis and transmission of SARS-CoV-2
- Vaccine and treatment generation against SARS-CoV-2
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What are some features of the LVG Golden Syrian Hamster?
- High level of sequence homology with human ACE2 receptor
- Consistent infection with SARS-CoV-2
- Maximum clinical signs such as alveolar damage, high lung viral load, cytokine activation, spleen and lymphoid atrophy, and development of serum antibodies