SJL VAF/Elite® Mouse Details
Selected by James Lambert in 1955 from 3 different strains of Swiss Webster brought to Jackson Laboratory between 1938 and 1943. This strain was introduced to CNRS-CSEAL, Orleans, France, in 1978, and acquired by IFFA CREDO in 1990 at the 114th generation. To Charles River in 1997.
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LOCATION: Raleigh
UNIT: R04E
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LOCATION: Wilmington
UNIT: W08
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SJL VAF/Elite® Mouse Details
Selected by James Lambert in 1955 from 3 different strains of Swiss Webster brought to Jackson Laboratory between 1938 and 1943. This strain was introduced to CNRS-CSEAL, Orleans, France, in 1978, and acquired by IFFA CREDO in 1990 at the 114th generation. To Charles River in 1997.
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Please email us at [email protected] to request a health report for this model.
For additional information, including pricing details, please visit the SJL mouse page on the Vital River Laboratories website.
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Frequently Asked Questions About SJL VAF/Elite® Mice
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What are the historical background and genetic characteristics of the SJL mouse?
SJL mice were originally derived from the Swiss strain of mice. SJL stands for Swiss Jim Lambert. These SJL mice, introduced in 1974, are known for their unique genetic characteristics and their role in pre-clinical research. Due to their special features, they are highly valuable in studying autoimmune diseases such as multiple sclerosis and specific histocompatibility complex (MHC) alleles.
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What are the advantages of SJL mice for preclinical research in neurobiology and immunology?
SJL mice have proven to be invaluable in various research areas, particularly in immunology and neurobiology.
Their genetic predisposition to autoimmune diseases makes them highly beneficial in studies related to understanding pathogenesis and potential treatments for conditions like multiple sclerosis. Their susceptibility to certain diseases and MHC alleles helps scientists to better understand immune responses, tolerances, and potential interventions.
Autoimmune diseases such as multiple sclerosis, which is a chronic disease related to the central nervous system, has been the focus of many researchers. The genetic features of SJL mice make them good models for studies involving neuroinflammation and demyelination, which are the indications of diseases such as MS. Furthermore, the SJL mice strain carries the susceptible genetic background commonly seen to develop experimental autoimmune encephalomyelitis (EAE) in mice.
EAE models are the most commonly used mice in studies of MS, as they have T cell-mediated central nervous system demyelination. MS presents in various clinical forms including attacks of optic neuritis, incidences of relapsing and remitting paralysis, and sensory deficits and more progressive deteriorations. Even though no animal model can exactly mimic the range of heterogeneity of human MS and its distinction in clinical and radiological displays, over the last decades EAE animal models that share clinical and neuropathological changes with human disease have been proven to be helpful to researchers.
SJL mice are also used by researchers for looking into the role of specific genes in autoimmune disorders and helping to establish the knowledge of these disease progressions and causal factors and finding potential treatments. -
What role do SJL mice play in radiation-induced cancers?
The SJL mouse earned its popularity first got the attention of in vivo researchers during the 1960s because of its ability to develop reticulum cell neoplasms (type B, RCN B) at a high frequency in both males and females around the age one year. The neoplasms that developed were histologically similar to Hodgkin disease and thus, the SJL strain was proposed as an investigative model of such lesions.
Citations: (Dunn, 1954; Haran-Ghera, Kotler, & Meshorer, 1967; Haran-Ghera et al., 1997; Haran-Ghera, Resnitzky, Krautghamer, & Tartakovsky, 1992)