Discovery

One CRO partner and one point of contact simplifies project management efforts, keeps costs down, and results in the best scientific outcomes. With the new One Step service by Charles River, clients have an accessible and knowledgeable advocate, from bench to bedside.

We offer early research and proof-of-principle in vitro and in vivo pharmacology studies in relevant cell and animal models of human diseases to aid the evaluation of efficacy. Our scientific team has extensive experience with the selection of animal models, assays and endpoints across key therapeutic areas. We can also work with clients to design new models to meet the specific needs of a particular compound or discovery program.

Therapeutic areas include:

• Cardiovascular/Metabolic disease
• Inflammation and immunology
• Musculoskeletal disease
• Neuroscience
• Ocular disease
• Oncology
• Rare disease
• Respiratory and fibrosis

Our study directors work closely with clients to design an in vivo or in vitro DMPK study using a range of administration routes, dosing regimens, and species to meet a molecule’s unique needs. These include selection of the appropriate biomarkers and endpoints that will be indicative of a molecule’s effect in order to relate dosing to outcomes.

Our capabilities include:

• Discovery bioanalysis
• In vitro and in vivo ADME screening
• In vivo PK screening
• Pharmacodynamic screening

Complex cellular assays, including RNAi cell lines and human primary cell-based assays, allow us to accelerate discovery programs by screening in biologically relevant systems. Combining proprietary adenoviral technology with complex cellular assays allows us to deliver novel, validated drug targets in multiple therapeutic areas.

Our award-winning chemistry team is well equipped to address the challenges of drug discovery projects, offering services across all aspects of drug discovery chemistry, including specialized route development (e.g., infusion, inhalation) and optimization.

Our chemistry services include:

• Medicinal chemistry
• Analytical chemistry
• Computer-aided drug design
• Process and scale-up chemistry
• Synthetic chemistry

We offer a unique combination of target class and cell biology expertise together with state-of-the-art instrumentation to provide services tailored to client requirements. The collaborative environment shared by our teams in medicinal chemistry, ADME, structural biology and fragment-based drug discovery allows them to deliver within challenging timelines.

Our offerings include:

• Biochemical to phenotypic assays
• Cell biology and cell line generation
• High-throughput screening
• High-content screening
• Compound screening libraries
• Orthogonal screening platforms
• Natural product screening
• Fragment-based drug discovery
• Novel biomarker identification
• Ion channel drug discovery

We support gene-centric discovery studies, from gene overexpression, gene knockdown, to gene knockout. We provide a wide range of products in the form of expression plasmids, AAV, lentivirus, and adenovirus to help to deliver genes into cells and tissues.

No matter what stage of research, we will help design and produce viral particles to best meet your needs. In addition to our variety of catalog products supporting your research programs, we also offer viral packaging, from small-scale packaging for in vitro work, to large-scale packaging required for animal studies, all the way to GMP production for use clinical/commercial applications.

With extensive knowledge of in vitro ADME gained through working within drug discovery environments at both pharmaceutical and biotech companies, our ADME experts offer a consultative approach, ensuring that the right experiments are performed at the right time.

Studies include:

• Detailed metabolic studies
• Distribution
• Drug-drug interactions
• Metabolic stability
• Physicochemical properties