"Genetic drift occurs in any independent mouse breeding colony and can potentially impede reproducibility and accurate scientific conclusions. Spontaneous mutations caused by genetic drift may go unrecognized for years, until the specific research questions that depend on such mutations are painstakingly addressed."
Download this whitepaper to learn more about:
- What genetic drift is, why it impacts study results, and how quickly it can develop
- Why genetic drift is more common in smaller colonies than larger ones
- Published examples of where heritable phenotypic differences between substrains have arisen
- How to limit genetic drift while promoting reproducibility and responsible animal use
Author: Kaya Ghosh, Ph.D, Technical Information Scientific Consultant, The Jackson Laboratory
Charles River is the exclusive distributor of JAX® Mice and select research services in Europe, Korea, and Taiwan.
