Explore Our Preclinical Facility
~309,000
square feet
~520
scientists
170
rooms
Toxicology
Access a range of toxicology services from the experts at our Ashland site. Our scientific team is skilled in evaluating the potential toxicity of your drug or chemical candidate to determine its potential risks and benefits, which can be used to provide a basis for regulatory approval:
- General toxicology
- Single-dose, sub-chronic, chronic, and carcinogenicity
- Standard and specialty routes of administration
- Infusion toxicology
- Inhalation toxicology (nose-only and whole-body)
- Developmental and reproductive toxicology
- Standard and nonstandard DART studies
- Investigative and endocrine toxicology
- Juvenile toxicology
- Neurotoxicology (acute, sub-chronic, and developmental)
- Genetic Toxicology (in vivo micronucleus, Comet and TGR Mutation Assay (Big Blue Transgenic Rodent Assay)
Pathology
We have a suite of pathology services available to assess pathologic changes for your candidate. These services include, but are not limited to, clinical pathology, histopathology, and necropsy. Ashland’s board-certified veterinary pathologists are internationally known experts in inhalation pathology, neuropathology and development, and reproductive pathology (both male and female).
Laboratory Services
Our experts at our Ashland site can perform laboratory services to fit your program’s tight timelines and requirements. The preclinical facility offers analytical and bioanalytical services, immunology, and immunotoxicology services to determine the most appropriate immune-related endpoints, formulations/pre-formulations services, and drug and metabolite concentrations from biological matrices.
- Analytical services
- Clinical chemistry
- Bioanalytical chemistry (nonclinical and clinical samples)
- Analytical chemistry
- Pharmacokinetics/toxicokinetic
- Immunology and immunotoxicology
- Flow cytometry
- T-cell dependent antigen response
- Cytokine analysis
- Receptor occupancy
- Formulations/pre-formulation services
Very happy to overview our outstanding experience with studies conducted with Charles River Laboratories in Ashland, OH. Excellent previous study experience provided and informed basis to select Charles River to conduct our study work. We leveraged findings and learnings from pilot studies conducted by them, to develop an acceptable pivotal study protocol for the FDA.”
Charles D. Miller DVM, PhD, VetSafe, LLC
Other Service Areas and Study Types
Our Ashland site offers other services and studies that can meet your drug development needs, ranging from pharmacology studies to endocrine disruptor screening:
- Efficacy pharmacology
- EEG studies
- Discovery toxicology
- High-throughput PK (HTPK)
- Safety pharmacology
- Target animal safety studies
- Compound shipping services
- Endocrine disruptor screening
- Investigative endocrinology and DART studies