Property Analysis of Molecule in Solution and Solid-State

A full knowledge and understanding of the properties of a compound is essential in drug discovery. Charles River can measure a wide variety of molecular properties in both the solid and the solution state to facilitate rapid development.

Physical Properties of Compounds

  • LogP, pKa, logD
  • Melting points and other thermal events using DSC
  • Degradation using TGA and TGA-IR
  • Hygroscopicity using DVS
  • Particle size
  • Particle morphology using SEM
  • Lactose blend performance using NGI technology
Design composed of conceptual atoms, molecules, and fractal elements as a metaphor on the subject of toxicology

Off-target Toxicities and Links with Physicochemical Properties of Medicinal Products
This article discusses the risks of off-target and/or non-specific toxicities that may be associated with the physicochemical properties of compounds, especially those carrying dominant positive or negative charges.
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