Brown Norway Rat Details
Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976.
LOCATION: Raleigh
UNIT: R08
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Brown Norway Rat Details
Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976.
Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.
UNIT: 008
Download the Report
➤ DOWNLOAD OUR CATALOG for instant access to Standard List Pricing
➤ TALK TO US to discuss organization or volume-based discounts
Already have an eCommerce portal account?* Login to order research models, obtain quotes, view organization-specific pricing, and see inventory. Processing time required to validate new eCommerce access requests.
*eCommerce is available in US, Canada, UK, France, Germany, Austria, Netherlands, Denmark, Finland, Norway, Sweden, Spain, Portugal, Belgium, Luxembourg, and Switzerland
Brown Norway Rat Details
Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976.
Please email us at [email protected] to request a health report for this model.
For additional information, including pricing details, please visit the Brown Norway rat page on the Vital River Laboratories website.
One key benefit of using the Brown Norway rat in respiratory work is its consistent response in allergic models. Its unique lung immunology and pathophysiology makes it distinctive among rat strains.
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References
Wagner, E. M. et al. Angiogenesis and Airway Reactivity in Asthmatic Brown Norway Rats. Angiogenesis. 18(1), 1-11 (January 2015).
Chapman, R. W. et al. Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration. The European Journal of Pharmacology. 643(2-3), 274-81 (September 2010).
Lin et al. Hypersensitivity of vagal pulmonary C-fibers induced by increasing airway temperature in ovalbumin-sensitized rats. The American Journal of Physiology — Regulatory, Integrative and Comparative Physiology. 309(10), R1285-91 (November 2015).
Down, K. et al. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase & for the Treatment of Respiratory Disease. Journal of Medicinal Chemistry. 58(18), 7381-7399 (August 2015).
Ramis et al. A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response. Pharmacological Research. 99, 116-24 (September 2015).
Pauluhn, J. et al. Development of a respiratory sensitization/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level. Toxicology. 319, 10-22 (May 2014).