Asthma Models CRO
Leverage our expertise with a wide array of well-characterized in vivo models, a variety of administration routes (including inhalation), and clinically relevant endpoints to tailor your respiratory discovery projects. When using our models, total and differential cell counts of inflammatory cells in the lung are performed on the bronchoalveolar lavage (BAL) fluid at various time points to observe the time course of inflammation and evaluate the effects of compounds. Additional services that can be combined with our asthma models can include inflammatory mediators, histopathologic evaluations, and assessments of airway hyperresponsiveness.
House Dust Mite-induced Allergic Asthma Mouse Model
The House Dust Mite (HDM)-induced asthma model in the mouse is used to assess the in vivo efficacy of anti-asthma drugs. This model features many similarities to human allergic asthma, including the presence of eosinophilic lung inflammation and the release of inflammatory mediators and cytokines primarily associated with Th2-type inflammation. The model is robust and reproducible and sensitive to steroids (both oral and inhaled).
Ovalbumin (OVA)-induced Allergic Asthma Rat and Mouse Model
The ovalbumin (OVA)-induced asthma model in the Brown Norway rat is used to assess the in vivo efficacy of anti-asthma drugs. This animal model features many similarities to human allergic asthma, including the presence of eosinophilic lung inflammation, the release of inflammatory mediators, and cytokines, and the presence of airway hyperresponsiveness after the antigen-challenge.
Alternaria alternata-induced Asthma Rat Model
In man, exposure to the fungal spore Alternaria alternata is a risk factor for asthma and can exacerbate clinical symptoms. The Alternaria alternata-induced asthma model in the Brown Norway rat is used to assess the in vivo efficacy of anti-asthma drugs. This animal model features many similarities to human allergic asthma, including the presence of eosinophilic lung inflammation and the release of inflammatory mediators and cytokines primarily associated with Th2-type inflammation. The model is robust, reproducible, and sensitive to steroids (both oral and inhaled).
Available Endpoints for Asthma Studies
- Flexivent lung function evaluation
- Bronchoalveolar lavage (BAL) with leukocyte differential counts
- Clinical scores
- Histopathology
- Biomarker analysis (gene, protein expression patterns)
- Cytokine analysis
- Clinical chemistry
- PK/PD blood analysis
We offer a range of other respiratory studies, including LPS-induced pulmonary neutrophilia.