CD-1® IGS Mouse Details
The original group of Swiss mice that served as progenitors of CD-1 mice consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research (ICR) in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To Charles River in 1959. IGS refers to animals bred using the Charles River International Genetic Standardization system.
Note: We also offer the CD1 VAF/Elite® Mouse with a VAF/Elite® health profile (bred in NA) and the CD1 SOPF Mouse with an SOPF health profile (bred in France).
LOCATION: Kingston
UNIT: K84
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LOCATION: Raleigh
UNIT: R03
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LOCATION: Raleigh
UNIT: R10
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LOCATION: Hollister
UNIT: H43
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CD-1® IGS Mouse Details
The original group of Swiss mice that served as progenitors of CD-1 mice consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research (ICR) in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To Charles River in 1959. IGS refers to animals bred using the Charles River International Genetic Standardization system.
Note: We also offer the CD1 VAF/Elite® Mouse with a VAF/Elite® health profile (bred in NA) and the CD1 SOPF Mouse with an SOPF health profile (bred in France).
Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.
UNIT: 10
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➤ TALK TO US to discuss organization or volume-based discounts
Already have an eCommerce portal account?* Login to order research models, obtain quotes, view organization-specific pricing, and see inventory. Processing time required to validate new eCommerce access requests.
*eCommerce is available in US, Canada, UK, France, Germany, Austria, Netherlands, Denmark, Finland, Norway, Sweden, Spain, Portugal, Belgium, Luxembourg, and Switzerland
Try out this model with our animal evaluation program (North America)
Try out this model with our animal evaluation program (Europe)
CD-1® IGS Mouse Details
The original group of Swiss mice that served as progenitors of CD-1 mice consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research (ICR) in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To Charles River in 1959. IGS refers to animals bred using the Charles River International Genetic Standardization system.
Note: We also offer the CD1 VAF/Elite® Mouse with a VAF/Elite® health profile (bred in NA) and the CD1 SOPF Mouse with an SOPF health profile (bred in France).
Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.
UNIT: A10
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UNIT: A57
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➤ DOWNLOAD OUR CATALOG for instant access to Standard List Pricing
➤ TALK TO US to discuss organization or volume-based discounts
Already have an eCommerce portal account?* Login to order research models, obtain quotes, view organization-specific pricing, and see inventory. Processing time required to validate new eCommerce access requests.
*eCommerce is available in US, Canada, UK, France, Germany, Austria, Netherlands, Denmark, Finland, Norway, Sweden, Spain, Portugal, Belgium, Luxembourg, and Switzerland
Try out this model with our animal evaluation program (North America)
Try out this model with our animal evaluation program (Europe)
CD-1® IGS Mouse Details
The original group of Swiss mice that served as progenitors of CD-1 mice consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research (ICR) in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To Charles River in 1959. IGS refers to animals bred using the Charles River International Genetic Standardization system.
Note: We also offer the CD1 VAF/Elite® Mouse with a VAF/Elite® health profile (bred in NA) and the CD1 SOPF Mouse with an SOPF health profile (bred in France).
Growth chart data should be used as a guideline only.
The shaded areas on each chart are the mean weight plus or minus one standard deviation at a given age averaged across all production facilities. This represents approximately 67% of the population, with the remaining 33% falling outside of this weight range.
UNIT: 3
Download the Report
➤ DOWNLOAD OUR CATALOG for instant access to Standard List Pricing
➤ TALK TO US to discuss organization or volume-based discounts
Already have an eCommerce portal account?* Login to order research models, obtain quotes, view organization-specific pricing, and see inventory. Processing time required to validate new eCommerce access requests.
*eCommerce is available in US, Canada, UK, France, Germany, Austria, Netherlands, Denmark, Finland, Norway, Sweden, Spain, Portugal, Belgium, Luxembourg, and Switzerland
Try out this model with our animal evaluation program (North America)
Try out this model with our animal evaluation program (Europe)
CD-1® IGS Mouse Details
The original group of Swiss mice that served as progenitors of CD-1 mice consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research (ICR) in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To Charles River in 1959. IGS refers to animals bred using the Charles River International Genetic Standardization system.
Note: We also offer the CD1 VAF/Elite® Mouse with a VAF/Elite® health profile (bred in NA) and the CD1 SOPF Mouse with an SOPF health profile (bred in France).
Please email us at [email protected] to request a health report for this model.
For additional information, including pricing details, please visit the CD-1® mouse page on the Vital River Laboratories website.
Try out this model with our animal evaluation program (North America)
Try out this model with our animal evaluation program (Europe)
GUIDEBOOK
Rodent Model Genetic Quality Control
Learn the essentials of genetic QC programs: inbred/outbred colony quality control, transgenic rodent model creation, rederivation, and cryopreservation techniques. Download Now
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Genetic Management of the CD-1® IGS Mouse Colony
Charles River uses the IGS program to manage production of the Crl:CD1(ICR) mouse. The IGS program is a management system used to minimize inbreeding and manage random genetic drift that would otherwise lead to colony divergence among colonies bred in different locations worldwide. The IGS program is validated by direct genetic analysis of animals from the foundation colony and the barrier rooms. For the CD-1® mouse, analyses have been carried out on animals from the Wilmington, MA, foundation colony (2004 and 2010).
For the 110 microsatellite loci tested, average heterozygosity was not significantly different between the testing periods (28.1% versus 28.9%, respectively). These data indicate that the IGS program is working to maintain genetic variation in the CD-1® foundation colony and there has been no significant change in the overall level of variation during the six-year interval for testing.
Future testing for this and other IGS program colonies will be performed every three years for the foundation colony and every five years for each production colony. For further information regarding Charles River’s IGS program, please refer to the IGS technical sheet.
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Charles River CD-1® IGS Data
We understand that knowing certain baseline parameters for your research model colonies is vital to achieving valid and reproducible research results. To help ensure that we are providing the exact CD-1 mice models that you need, we conduct routine health surveillance on our animal colonies for an extensive list of infectious agents, in addition to maintaining clinical and toxicological data for those models.
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Clinical Chemistry
Crl:CD1(ICR)*
ALB (g/dl)
ALK (U/l)
ALT (U/l)
AST (Ul)
TBIL (mg/dl)
BUN (mg/dl)
Male Mean 2.99 154.63 45.08 80.55 0.32 14.68 S.D. 0.62 50.03 16.11 67.29 0.12 3.99 n 63 64 65 65 63 62 Female Mean 2.95 156.54 41.63 82.8 0.26 12.8 S.D. 0.96 51.1 13.91 39.85 0.09 3.81 n 54 52 54 55 52 50 Crl:CD1(ICR)*
Ca(mg/dl)
CI (meq/l)
CHOL (mg/dl)
CRE (mg/dl)
GGT (U/l)
GLU (mg/dl)
Male Mean 11.3 116.18 164.89 11.3 116.18 164.89 S.D. 0.6 11.06 27.95 0.6 11.06 27.95 n 61 45 64 61 45 64 Female Mean 10.73 117.8 133.15 10.73 117.8 133.15 S.D. 2.19 11.71 25.34 2.19 11.71 25.34 n 55 31 54 55 31 54 *North American colonies only / non-fasted values
+Potassium levels reflect acidosis caused by CO2 euthanasia
Age: 56 – 70 days
Diet: Purina 5L79 rodent chow
Temperature: 68 – 72°F
Humidity: 40 – 60%Crl:CD1(ICR)*
P(mg/dl)
K+ (meq/l)
Na(meg/l)
TP (g/dl)
TRIG (mg/dl)
Male Mean 11.23 15.28 150.85 5.38 192.4 S.D. 2.88 24.63 31.76 0.95 66.72 n 62 45 45 62 65 Female Mean 10.2 17.12 144.46 5.23 248.05 S.D. 2.81 29.8 36.96 1.13 100.74 n 52 31 31 52 57 *North American colonies only/non-fasted values
+Potassium levels reflect acidosis caused by CO2 euthanasia
Age: 56 - 70 days
Diet: Purina 5L79 rodent chow
Temperature: 68 – 72°F
Humidity: 40 – 60% -
Hematology
Crl:CD1(ICR)*
WBC(K/µl)
RBC (M/µl)
HGB (g/dl)
HCT (%)
MCV (fL)
Male Mean 8.79 8.93 14.67 49.97 56.1 S.D. 2.54 1.37 2.21 7.67 4.59 n 57 57 57 57 57 Female Mean 8.77 8.78 14.55 49.43 56.39 S.D. 2.95 1.12 2.05 6.7 3.75 n 58 58 58 58 58 Screening Period: August 2006 – November 2007
Euthanasia: CO2
Bleed Route: Cardiac puncture after euthanasia
Analyzing Equipment: Alfa Wassermann Ace AleraCrl:CD1(ICR)*
MCH
(pg)MCHC
(g/dl)RDW
(%)PLT
(K/µl)MPV
(fL)Male Mean 16.45 29.50 16.79 1528.88 5.09 S.D. 0.97 2.76 0.96 400.63 0.42 n 57 57 57 57 57 Female Mean 16.59 29.52 16.62 1383.53 5.06 S.D. 1.09 2.65 1.09 528.53 0.44 n 58 58 58 58 58 Crl:CD1(ICR)*
NEUT
(K/µl)LYMPH
(K/µl)MONO
K/µl)EOS
(K/µl)BASO
(K/µl)Male Mean 1.5 6.59 0.49 0.17 0.04 S.D. 0.84 1.9 0.19 0.15 0.05 n 57 57 57 57 57 Female Mean 1.34 6.7 0.5 0.17 0.04 S.D. 0.73 2.17 0.21 0.17 0.04 n 58 58 58 58 58 *North American colonies only / non-fasted values
Age: 56 – 70 days
Diet: Purina 5L79 rodent chow
Temperature: 68 – 72°F
Humidity: 40 – 60%
Cage Density: 5 in²/mouse
Bleed Route: Cardiac puncture
Analyzing Equipment: Drew scientific HemaVet -
Charles River Technical Data
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Research Applications and References
The CD-1® mouse is a multipurpose model that can be used in such fields as toxicology (safety and efficacy testing), aging, and oncology.
General Purpose
ToxicologyCarcinogenesis
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Additional Resources
Informational Resources: CD-1® MouseCD-1® IGS Mouse Model Information Sheet International Genetic Standardization (IGS) Program Technical Sheet Outbred Mice Information Model Data
Poster
Duration of Patency of Jugular Vein Catheters Attached to Transcutaneous Buttons in CD1 Mice without Maintenance