HuPBMC-NCG-B2m-KO Mice Details
In vivo models engrafted with human immune cells are essential for advancing research in immuno-oncology, infectious diseases, and graft rejection. Among these, peripheral blood mononuclear cells (PBMCs) are particularly valuable for humanizing mice due to their rapid engraftment in immunodeficient models.
The NCG-B2m-KO mouse is a next-generation triple-immunodeficient NCG model with a targeted B2m (β2-microglobulin) gene knockout. This modification disrupts β2-microglobulin (B2m) — a key component of the MHC complex — resulting in minimal MHC I expression on cell membranes. As a result, NCG-B2m-KO mice exhibit strong resistance to graft-versus-host disease (GvHD), making them an ideal platform for longer PBMC studies.
By combining NCG-B2m-KO mice with pre-qualified PBMCs, researchers can accelerate their studies with reliable and reproducible results – eliminating the need for additional donor cell qualification and streamlining the path to discovery.
The growth chart for the HuPBMC-NCG-b2m-KO is not available. This is the growth chart for the naïve NCG-b2m-KO.
LOCATION: Raleigh
UNIT: R09I
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LOCATION: Wilmington
UNIT: W09
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Download our catalog to view our portfolio and pricing. To place your HuPBMC-NCG-B2m-KO mice order, please contact [email protected].
Create Your Own PBMC Humanized Mouse Models
We offer the PBMC Select Humanization Kit so you can create humanized mouse models when your research requires them.