NCI SCID/NCr Mouse Details
SCID mice possess a genetic autosomal recessive mutation Prkdcscid. Discovered in 1980 by Bosma in C.B-17/Icr mice at Fox Chase Cancer Center. SCID mice show a severe combined immunodeficiency affecting both B and T lymphocytes. They have normal natural killer (NK) cells, macrophages and granulocytes. NCI received this mouse in 1991. To Charles River in 2014.
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LOCATION: Raleigh
UNIT: R09I
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Immunodeficient Model Selection Poster
Compare immune cell deficits (T/B/NK), engraftment applications, and practical study considerations (e.g., leakiness and radiation tolerance) side-by-side across multiple immunodeficient mouse and rat models. Download Poster
Technical Resources
- Health Monitoring of Immunodeficient Rodents in Isolators in North America and Europe
- Immunodeficient Mice
Did You Know We Deliver Drug Discovery Services from Day One?
Charles River offers a range of translational oncology studies, including in vitro assays and in vivo models, that mirror human cancers. Whether you want to test your therapy in a cell biology assay consisting of the elements of the tumor microenvironment or in models using real patient tissue, we can help.
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