Physicochemical Testing
Your registration timelines are dependent on our ability to keep your physicochemical analysis on track, regardless of challenges that may arise. With a full range of physicochemical testing capabilities to meet all regulatory requirements, Charles River has conducted successful physicochemical analysis programs for various biocide, agrochemical, and pesticide classes, including insecticides, herbicides, and fungicides. We have also worked with a wide variety of industrial chemicals, including dyes, flavor and fragrance substances, monomers, fluorinated chemicals, and inorganics. Data from our physicochemical analysis has been successfully accepted in support of numerous registrations throughout regions including Europe (e.g. ECHA, REACH etc.), North America (e.g. EPA etc.) and Asia.
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Physicochemical Testing Services
- Partition coefficient
- Appearance
- Melting and freezing points
- Boiling point
- Vapour pressure
- Relative density
- Surface tension
- Critical micelle concentration water solubility
- Organic solvent solubility
- Dissociation constant
- Flammability
- Flammability in contact with water
- Flash-point
- Auto-ignition temperature
- Self-Ignition/self-heating temperature
- pH
- Viscosity
- Corrosion to metals oxidizing or reducing properties
- Pyrophoric properties
- Screening for explosive or self-reactive properties
- Rate of hydrolysis (cold)
- Adsorption/desorption co-efficientSpectral analysis (UV, UV/Vis, IR, H1-NMR, MS)
- Several CIPAC testing methods (e.g. persistent foaming, dispersion stability, etc.)
Expertise in Physicochemical Analysis
With a staff of more than 20 scientists dedicated to physicochemical analysis, our team completes approximately 300 analytical packages per year. Our experts are skilled in a full array of analytical techniques, including LC, LC-MS, GC, GC-MS, and ICPS-MS and can provide analytical support for both storage stability as well as phys-chem characterization. We specialize in the physicochemical analysis of a wide variety of materials, ranging from pure, stable substances up to complex mixtures and UVCBs as well as reactive matter.
Our scientists are also able to provide numerous physicochemical testing expert statements, with or without the use of screening techniques such as DSC, to offer our clients the most economical testing strategies.
Storage Stability Testing
The storage stability and shelf life of a formulated product can be determined under a variety of specified storage conditions. Solid, liquid and semi-solid formulations can all be evaluated using real-time and accelerated storage stability testing. We have dedicated facilities to stress the material using monitored heat and humidity.
Analytical Platforms for Physicochemical Testing
- UPLC (UV, LIF, fluorescence, refractive index, light scattering, electrochemical)
- GC (FID, NPD, TCD, ECD)
- LC-MS, GC-MS, GC/LC-MS-MS, time-of-flight (Q-ToF, IT-ToF)
- Dionex ion chromatograph (conductivity)
- ICP-OES (Optima™ 8000)
- ICP-MS
- Isothermal Thermogravimetric Analysis (TGA)
- Differential Scanning Calorimetry (DSC)
Frequently Asked Questions (FAQs) for Physicochemical Testing
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Which guidelines cover the physicochemical testing of industrial chemicals?
A chemical is subject to the guidelines of the regulatory body with which it will be registered. The physicochemical testing at Charles River is designed to meet all relevant regulatory requirements of the major global markets, such as OECD Guidelines, TSCA, and EPA guidelines.
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Which guidelines cover the physicochemical and stability testing of agrochemical and biocidal products?
Similarly, the testing of an agrochemical or biocidal product must follow the guidelines of eventual regulatory body with which it is registered. The storage stability studies at Charles River are designed to meet all relevant regulatory requirements of the major global markets, including the United Nations, European Union, the EPA, and CIPAC.