Webinar Overview
Tumor cell dissemination into systemic circulation is challenging to study in vivo due to a lack of immunodeficient animal models able to support larger xenograft tumors and blood collection. In this webinar, hear how researchers at Fred Hutchinson Cancer Center analyzed the dynamics and molecular mechanisms of breast cancer dissemination with the triple-immunodeficient SRG rat.
In this webinar, they review several key findings, including:
- Increased detection of both single circulating tumor cells (CTCs) and CTC clusters with the SRG (10-fold compared with mice)
- The ability of the SRG to support larger primary tumors (compared to mice)
- The mouse-to-rat xenograft and how it allowed the deconvolution of transcripts that were tumor or host-derived
Webinar Presenters
Kevin Cheung, MD
Associate Professor
Fred Hutchinson Cancer Center, University of Washington
Ami Yamamoto, BS
PhD Candidate
University of Washington