Keeping pace in an industry focused on revolutionizing science and innovation, we’ve evolved and refined the next addition to our bacterial endotoxin detection portfolio with Endosafe® Trillium™, a recombinant cascade reagent (rCR) assay.
Across two one-hour webinars, we will explore how Trillium detects and quantifies natural environmental endotoxins by simulating the LAL enzymatic cascade. This is accomplished through an optimized formulation and composition of 3 critical recombinant proteins. Q&A sessions with our experts will be included in both sessions.

Animal-Free Endotoxin Testing with Endosafe® Trillium™
In the pursuit of developing an alternative to the horseshoe crab-derived endotoxin test, we’ve conducted scientifically sound studies, analyzed real-world data, challenged the results, and optimized our reagent formulation. This resulted in the creation of a recombinant cascade reagent (rCR) that falls under our Endosafe® portfolio, and lives up to our customers, and industry expectations.
In the first webinar of this series, you will learn:
- What Trillium and a recombinant cascade reagent are
- How Trillium can support your commitment to the 3Rs initiatives
- An overview of product test data and results

A Simple Framework for Validating & Implementing a Recombinant Cascade Reagent
Product validation is a critical step in bacterial endotoxin testing. That’s why we provide comprehensive validation protocols and implementation support. Our industry-proven technical teams have experience in successfully validating alternative microbiological methods. They possess over 40 years of endotoxin testing, troubleshooting, method development experience, and will be by your side throughout the implementation process.
In the second part if this series, you will learn about:
- Global regulators’ acceptance status and expectations of recombinant cascade reagent (rCR)
- Our full alternative method validation approach for an rCR
- An overview of results and findings as well as relevant comparability data
Webinar Presenters

Endosafe® Trillium™ Behind the Scenes: Expert Insights
Discovering breakthroughs in science is far more complex than just testing assumptions and drawing conclusions. Hear from our experts as they talk through their robust framework for making informed, data-based decisions and how Trillium came to fruition.
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A Step-By-Step Process to Validating rCR Endotoxin Testing
In this webinar you'll learn how we beta tested and validated our animal-free Endosafe® Trillium™ recombinant cascade reagent (rCR) to surpass even the most stringent sustainability standards, setting the bar in QC for endotoxin testing and easy implementation.
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Related Resources

USER GUIDE
Endosafe® Trillium™ Recombinant Cascade Reagent (rCR) Frequently Asked Questions
Frequently Asked Questions about the animal-free recombinant cascade reagent.
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WHITE PAPER
Endosafe® Trillium™ A Recombinant Cascade Reagent (rCR) Brochure
Learn more about this robust, animal-free recombinant cascade reagent.
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FEATURED PRODUCT
Endosafe® Trillium™ Recombinant Cascade Reagent (rCR)
A robust, animal-free recombinant cascade reagent (rCR)
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