Academic institutions rely upon qualified suppliers to provide the basic necessities to conduct their research and support their advancements. Each major advancement in science contributes to the base knowledge and new tools that make it easier to translate discoveries into practical treatments. We contribute by providing research animal models and various services, such as model creation services and research animal diagnostics, to support principle investigators at academic and research institutions globally.
- Animal Models
- Genetically Engineered Model Services
- Animal Health Surveillance
- Preconditioning Services
- Staffing & Staff Training
- Biologics Manufacturing
- Biologics Testing Solutions
- Viral Vector Packaging and Virus/Plasmid Products
We understand that selecting the appropriate animal model for your studies is critical to your research success. We provide high-quality genetically standardized models for use in basic research and nonclinical drug discovery and development. Our animals are bred under stringent biosecurity guidelines and cared for using humane and ethical treatment principles. Through our global network of commercial breeding facilities, we can provide you with an animal model to meet your specific research needs.
We work with hundreds of customers globally on thousands of unique genetically engineered models to deliver study-ready cohorts to meet research needs. Our team of scientists, project managers, and animal care staff is able to offer guidance, develop work plans, and help overcome any challenges with unique models. Learn more
Genetically Engineered Model Services
In today’s challenging research environment, vast resources are allocated to ensure that investigators have the necessary tools to meet their study goals. We help maintain research integrity by providing the most comprehensive portfolio of solutions for monitoring the health of study animals. Learn more
Animal Health Surveillance Products and Services
Our preconditioning services can alleviate the space, time, and labor costs involved with refining a model to meet your research requirements. Whether you are looking for animals fed a special diet, altered through surgery, or reared to a certain age, we have the technology and expertise to deliver study-ready animals right to your door. Learn more
Preconditioning Services
Recruiting and managing talented scientific and vivarium staff to support your research is a major undertaking. Charles River Insourcing Solutions℠ supports these efforts by supplying a wide range of scientific talent, including:
• laboratory technicians
• Scientists (MS to PhD level)
• Managers (project, laboratory, animal facility, etc.)
• Board-certified veterinarians
• Technically skilled veterinary technologists
• Cage wash and animal husbandry personnel
• “Cage to benchtop” transgenic technicians
• Embryo cryopreservationists
• Aquatic specialists
• Administrative professionals
In addition to staffing needs, our services support training, assistance in preparation of SOPs, accreditation preparation and quality assurance, and biosecurity audits and evaluation reports.
Insourcing Solutions℠ Services
From early preclinical formulation development through clinical and commercial product release, we provide timely, tailored science, and trusted products and services to support the development of your biologic.
Antibody/Protein Manufacturing
Our team of scientists can ensure the quality, consistency, and integrity of a client's cell and viral banks, promoting a smooth and successful outcome for their manufacturing campaigns.
Our manufacturing/production capabilities include:
- Mammalian and microbial cell banking
- PhI/II vaccines and viral challenge stocks
- Monoclonal and polyclonal antisera production
Cell and Gene CDMO Solutions
With the benefit of a shared quality system, faster internal technical transfer, and process crossover between teams helping to reduce program bottlenecks and providing a seamless experience, we are uniquely positioned to help our cell and gene therapy clients accelerate and achieve critical development goals from discovery to commercialization. We have supported the development of 10 FDA-approved cell and gene therapies and have conducted more than 900 studies in this field over the past year. Our aim is to enhance client access to this wealth of scientific and regulatory experience as well as harnesses the power of our multidisciplinary bench of experts to problem solve in a collaborative manner every step of the way.
Explore our cell and gene therapy CDMO solutions:
The approval process for ensuring the identity, potency, purity, safety, and effectiveness of a biologic is complex, and its effective navigation is critical to the ultimate commercial success of a product. With more than 50 years of experience, our Biologics Testing Solutions group has the proven knowledge, expertise, and capacity to address challenging projects for biotechnology and pharmaceutical companies worldwide. Our primary emphasis is on quality, which is enforced through continuous training and internal audit programs, ensuring that our practices are in compliance with global regulatory guidelines.
We support clients throughout the drug development continuum, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Our facilities in the US, UK, Ireland, France, and Germany are part of a global scientific network, allowing us to offer clients greater flexibility, experience, and expertise to maximize resources and optimize results based on specific program needs.
Our comprehensive biologics testing services include:
We support gene-centric discovery studies, from gene overexpression, gene knockdown, to gene knockout. We provide a wide range of products in the form of expression plasmids, AAV, lentivirus, and adenovirus to help to deliver genes into cells and tissues.
No matter what stage of research, we will help design and produce viral particles to best meet your needs. In addition to our variety of catalog products supporting your research programs, we also offer viral packaging, from small-scale packaging for in vitro work, to large-scale packaging required for animal studies, all the way to GMP production for use clinical/commercial applications.
Custom Virus Packaging
• AAV packaging services
• Lentivirus packaging services
AAV Products
• AAV reference materials
• AAV control viruses
• AAV biosensors
• AAV Parkinson’s Disease tools
Lentiviral Products
• Human ORF Lentivirus
• Lentiviral control particles
The Disruptors: Conversations in Science
Take a closer look at how Dr. Wise Young and his team at W.M. Keck Center for Collaborative Neuroscience are bringing effective treatments to people with spinal cord injury.
Meet Wise