Neurochemistry: Bioanalysis Services

Accuracy and sensitivity are critical parameters for neurotransmitter detection. Our state-of-the-art equipment allows us to offer novel analytical techniques, including SymDaq, our proprietary derivatizing agent, to support analysis of low concentrations of multiple neurotransmitters simultaneously in a single run. Additionally, we can develop novel study designs based on your specific needs for sample preparation, quantification, and analysis.

Image of person looking at resources on a computer with a cup of coffee. Charles River has many resources for Neurochemistry & Electrochemistry to aid your research.

Neurochemistry Resources
Check out our Neurochemistry posters, publications, and other scientific resources.
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Sym DAQ LC-MS enables simultaneous analyses of multiple neurotransmitters in a single dialysis sample

An LC-MS plot of multiple neurotransmitters in a single dialysate sample by the Charles RIver proprietary SymDAQ technology.

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Does Ketamine Really Modulate Glutamate?
Learn how to quantify multiple transmitters at once using SymDAQ technology.
Download the Poster

Neurochemistry Tools and Sample Types:

  • Neurochemistry Bioanalytical Tools:
    • HPLC – tandem mass spectrometry
    • HPLC – electrochemical detection
    • HPLC – fluorescence detection
    • RIA / ELISA
  • Biological Matrices:
    • CSF samples
    • Microdialysates
    • Brain tissue samples
    • Plasma, plasma free fraction or serum
    • In vitro matrices
    • Urine
    • Bone
    • Gut tissue
    • Liver
    • Kidney
    • Spleen
    • Human tissue (non-GLP)
    • Other biological tissues
    • Other biological fluids
  • Neurochemistry Analytes:
    • Acetylcholine
    • Amino acids (including GABA)
    • cAMP/cGMP
    • Glucose and lactate
    • Histamine
    • Monoamines (including NE, DA, and 5HT)
    • Exogenous compounds
    • Glucocorticoids
    • Kynurenines
    • Tryptophan
    • MA metabolites (including HVA, 5-HIAA, and DOPAC)
    • D- and L-Serine
    • Polyamines (including putricine and spermine)
    • Custom analyte service
Bioanalytical services include careful preparation of reference standards for a validated bioanalytical method standard curve to quantitate biological samples for drug concentrations.

Comprehensive Bioanalysis is Key at Every Stage of Product Development
Bioanalysis is intertwined with our:

  • Discovery in vitro, in vivo and ex vivo studies
  • Preclinical research
  • Clinical capabilities

Learn about our other Bioanalysis methods and tools

Have more questions on electrochemistry and neurochemical bioanalysis for your studies?

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Frequently Asked Questions (FAQs) for Neurochemistry

  • What kind of studies are performed using the SymDAQ technology?

    Detecting neurotransmitters and metabolites from many different types of disease models can be studied using SymDAQ. For example, dialysates analyzed by the SymDAQ HPLC-tandem-mass spectrometry technology for serotonin (5-HT), and metabolites (5-HIAA, 3,4-dihydroxyphenylacetic acid and homovanillic acid) is frequently used for simultaneous determination of monoamines and amino acids in a depression model.

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