86%
of neuroscience FDA approvals worked on in the past five years

15
small molecules delivered to our neuroscience clients

102
neuroscience patents

Neuroscience Drug Discovery

Our team of neuroscientists are experienced with a wide range of in vitro and in vivo models across all disease areas within neuroscience. We have developed robust and reproducible cellular models and in vivo pharmacology studies that are validated for multiple assay platforms and reliable tools to screen your therapeutic, from small molecules to biologics. To answer your neuroscience drug discovery questions, we partner with you to select the most appropriate models and readouts to build momentum as you work to bring new therapies to patients. Explore our models and assays for different diseases below.

Alzheimer’s Disease

Regardless of your target and therapeutic modality, we have the in vitro assays, in vivo models, and translational readouts to support your Alzheimer’s disease drug discovery.

Amyotrophic Lateral Sclerosis (ALS)

SOD1 and TDP-43 cell and transgenic mouse models, and motor and muscular functional tests enable ALS drug discovery across therapeutic modalities, including small molecules, ASOs, and siRNA therapeutics.

Batten’s Disease

Our models of Batten’s disease, a rare lysosomal storage disorder, are validated with fine motor and gait analysis, and neurological imaging methods to support drug discovery.

Duchenne’s Muscular Dystrophy (DMD)

In vitro assays using iPSC-derived myocytes and a validated X-linked muscular dystrophy (MDX) mouse model enable the discovery of novel small molecules, ASOs, and biologics for DMD.

Epilepsy

Epilepsy drug discovery services include high-throughput ion channel screening, iPSC-derived cell models, multi-electrode array electrophysiology, in vivo EEG, and translational rodent imaging techniques.

Huntington’s Disease

A comprehensive portfolio of cell models, HTT detection assays, functional assays, rodent models, motor function tests, and in vivo imaging services supports your Huntington’s disease drug discovery.

Migraine

Pharmacology induced models, alongside functional readouts of acute and chronic pain, and detection of cerebrovascular changes with in vivo imaging support your migraine drug discovery.

Multiple Sclerosis

In vitro models of oligodendrocytes and myelination, alongside in vivo models of inflammatory and demyelinating processes, support your multiple sclerosis drug discovery across biologics and small molecules.

Neuroinflammation

A variety of monoculture and complex cell models, functional neuroinflammation assays, and in vivo models support your neuroinflammation drug discovery.

Pain

The complexity and variety of drug discovery for pain disorders are supported by a wide range of models, assays, and technologies for acute, chronic, and neuropathic pain.

Parkinson’s Disease

Parkinson’s disease drug discovery is enabled with a variety of cell models, aggregation and mitophagy assays, and drug-induced and transgenic animal models.

Psychiatric Disorders

Drug discovery for complex psychiatric disorders requires a multi-factorial approach, which we support with intrinsic and environmental rodent models, and innovative methods and endpoints.

Spinal Cord Injury

Combinations of functional assessments, behavior and cognition testing, in vivo imaging, and biomarker analysis in gold-standard models support spinal cord injury drug discovery.

Stroke and Ischemia

We enable your stroke drug discovery with gold-standard models of both ischemic and hemorrhagic stroke, supported by functional assessments, preclinical in vivo imaging and biomarker analysis.

Traumatic Brain Injury

Repeated in-life measurements of drug efficacy and disease pathology enable longitudinal tracking of injury progression and therapeutic effect in gold-standard TBI models.
Illustration of Neurons
Exploratory Toxicology for Neuroscience Drug Discovery
This eBook describes strategies across the early stages of drug discovery to support confidence in your lead small molecule candidate and to ensure you proceed through the drug development process with the most promising candidate.
Read the eBook

Abuse Liability Testing

A requirement for all CNS-targeted drugs, abuse and dependence liability can be assessed in rats and large animal models via GLP self-administration, discrimination and dependence assays.

Behavior and Motor Tests

Our comprehensive range of behavior testing methods covers general welfare, locomotion and motor skills, cognition, learning and memory, as well as anxiety and depression-like behaviors.

Cell Models for Neuroscience Drug Discovery

Beyond the culture of a single cell type, complex co-culture models, combined with various readouts and measurements, improve translation in neuroscience drug discovery.

CNS Drug Delivery

Getting your drug to its site of action in the central nervous system is vital for therapeutic success. We have expertise in a range of surgical and imaging-guided methods of CNS drug delivery.

Electrophysiology Services

Electrophysiology technologies, such as high-throughput patch clamp screening, multi-electrode arrays, and quantitative EEG and EMG enable measurement of drug effects on neuronal function and activity throughout neuroscience drug discovery.

IND-Enabling Studies

Our IND-enabling studies are custom-designed to demonstrate the efficacy and safety of your drug, providing tailored solutions to decrease your development timelines.

In Vivo Imaging

Translational imaging techniques like MRI, PET and functional ultrasound enable repeated, non-invasive investigation of drug effects on disease pathology, brain function and anatomy, cerebral metabolism, and the cerebrovasculature.

Microdialysis

A powerful technique for repeated sampling of analytes, microdialysis enables profiling of drug effects on endogenous neurotumors and proteins, as well as PK/PD modeling of your therapy.

Neurotoxicity Testing Services

Neurotoxicity testing assesses the effect of a novel drug on the structure, chemistry, and function of the nervous system. Our experts combine their extensive experience with neurotoxicity readouts, methods and CNS drug administration routes.

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