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Webinar Overview
PBMC humanized mouse models (HuPBMC mice) are a valuable tool to assess the efficacy of human immunotherapies by recapitulating aspects of human tumor biology in an in vivo animal model. Donor variability refers to inherent differences in PBMC composition, function, and phenotype between donors that can affect various aspects of PBMC engraftment and function in humanized mice. Because of this, the reproducibility and consistency of your oncology studies can be that much more challenging.
View this webinar to see our scientific experts share data showcasing the impact of donor variability on the development of PBMC humanized NCG mouse models utilized for cancer studies.
You will learn about:
- PBMC collection and how utilizing recallable donors can maintain consistency in your assay development
- The effect of donor variability on PBMC engraftment rate and onset of graft versus host disease
- The effect of PBMC engraftment from different donors on tumor growth rate in HuPBMC mice
Webinar Presenters
Steven Bronson, DVM
Scientific Product Manager
Charles River
Wassim Basheer, PhD
Senior Product Manager - Cell Solutions
Charles River