The drug research and development process is highly complex, yet essential for delivering safe and effective therapies to patients. Even though the process is well defined, drug development programs are fundamentally different for each product.
To help our clients navigate this process, we offer a wide range of products and services that span the entire drug discovery and development continuum and can be tailored to specific research conditions.
- Basic Research
- Discovery
- Nonclinical Testing & Lab Support
- Biologics Manufacturing
- Biologics Testing Solutions
- Research & Ops Support
- Microbial Solutions
Charles River supplies and manages study-ready, preconditioned and genetically engineered animal models and services to support today’s most critical research. Pharmaceutical and Biotechnology companies around the globe depend on our extensive portfolio of models to study disease in critical therapeutic areas. We promote our client’s long-term success with world-class breeding, biology, diagnostics and health monitoring services.
Our expertly managed network of vivaria and breeding facilities adheres to the strictest biosecurity measures, and has earned the seal of approval from the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) International. Our commitment to genetic stability within our colonies ensures utmost model quality to achieve optimum study outcomes.
Basic Research Products & Services
Our Discovery team has a proven track record in the development of novel therapies in collaboration with our partners. Using the latest technologies and platforms, we support clients’ discovery programs across all major therapeutic areas, from hit ID to IND.
Our team takes a true collaborative approach, working with Pharmaceutical and Biotechnology clients to maintain transparency and establish trust. This partnership allows us to move forward together to bring novel therapies to the patients who need them.
Discovery Products & Services
From complete IND-enabling programs to stand-alone assessments, our Safety Assessment team provides a full range of in vivo and in vitro testing services that comply with worldwide regulatory restrictions for the preclinical development of pharmaceuticals.
Serving the needs of both small and large molecule developers, we offer a broad range of standard and specialized laboratory services to complement and enhance drug development programs, from discovery through safety and clinical trials.
Nonclinical Testing & Laboratory Support Products & Services
From early preclinical formulation development through clinical and commercial product release, we provide timely, tailored science, and trusted products and services to support the development of your biologic.
Antibody/Protein Manufacturing
Our team of scientists can ensure the quality, consistency, and integrity of a client's cell and viral banks, promoting a smooth and successful outcome for their manufacturing campaigns.
Our manufacturing/production capabilities include:
- Mammalian and microbial cell banking
- PhI/II vaccines and viral challenge stocks
- Monoclonal and polyclonal antisera production
Cell and Gene CDMO Solutions
With the benefit of a shared quality system, faster internal technical transfer, and process crossover between teams helping to reduce program bottlenecks and providing a seamless experience, we are uniquely positioned to help our cell and gene therapy clients accelerate and achieve critical development goals from discovery to commercialization. We have supported the development of 10 FDA-approved cell and gene therapies and have conducted more than 900 studies in this field over the past year. Our aim is to enhance client access to this wealth of scientific and regulatory experience as well as harnesses the power of our multidisciplinary bench of experts to problem solve in a collaborative manner every step of the way.
Explore our cell and gene therapy CDMO solutions:
The approval process for ensuring the identity, potency, purity, safety, and effectiveness of a biologic is complex, and its effective navigation is critical to the ultimate commercial success of a product. With more than 50 years of experience, our Biologics Testing Solutions group has the proven knowledge, expertise, and capacity to address challenging projects for biotechnology and pharmaceutical companies worldwide. Our primary emphasis is on quality, which is enforced through continuous training and internal audit programs, ensuring that our practices are in compliance with global regulatory guidelines.
We support clients throughout the drug development continuum, from the establishment and characterization of cell banks through preclinical and clinical studies to marketed products. Our facilities in the US, UK, Ireland, France, and Germany are part of a global scientific network, allowing us to offer clients greater flexibility, experience, and expertise to maximize resources and optimize results based on specific program needs.
Our comprehensive biologics testing services include:
Exceptional support of the entire drug discovery and development process is a Charles River hallmark. As a customer-focused organization committed to advancing science and helping clients reach their goals, we continually strive to develop solutions that extend our support of their efforts. Because our industry-seasoned professionals have followed the same journey as our clients, we can provide insight into the bigger picture, advice on best practices, skilled staff to extend resources and targeted training to meet the unique challenges they face along the way.
Research & Operations Support Products & Services
Our microbiology testing portfolio brings you progressive products and services that deliver accurate, relevant, and reliable data to make confident decisions on product quality and contamination control. Our unique combination of Endosafe® endotoxin testing, Celsis® rapid microbial detection, and Accugenix® microbial identification and strain typing keeps your manufacturing operations running efficiently and smoothly, lowers your cost to manufacture, and protects your reputation.