Animal Models of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks the joints, producing an inflammatory synovitis that often progresses to destruction of the articular cartilage and ankylosis of the joints. Charles River conducts contract studies in established mouse and rat models of rheumatoid arthritis to test the efficacy of novel therapeutics.
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| Model | Study Protocol |
|---|---|
| Collagen-Induced Arthritis (CIA) in Rats | 28-day study carried out in Dark Agouti or Lewis rats using bovine or porcine type II collagen as an immunogen. |
| Collagen-Induced Arthritis (CIA) in Mice | 49-day study carried out in DBA1 mice using bovine or chicken type II collagen as an immunogen. Disease onset can be synchronized with LPS challenge. |
| Collagen Antibody-Induced Arthritis (CAIA) in Mice | 21-day study bypassing the development of anti-collagen antibodies. Disease is induced using a cocktail of monoclonal antibodies directed against type II collagen. |
Study Endpoints
- Clinical scores
- Tactile allodynia (Von Frey fibers)
- Histopathology
- Biomarker analysis (gene, protein expression patterns)
- Cytokine analysis
- Clinical chemistry
- PK/PD blood analysis