Let's Talk About Sex Bias in Preclinical Research
One sex is far too often selected over the other in mouse-based research investigating new cures for human diseases. This sometimes happens for sound scientific reasons, and sometimes not. Omitting sex as a biological variable has several consequences - single-sex studies can not only lead to skewed research, translatability issues, and flawed conclusions – it also raises concerns regarding ethical practices and the 3Rs.
Sex bias creates animal welfare challenges related to animal over-production and wastage, insufficient consideration of welfare impact related to differential housing of male vs female animals within research facilities, and a lack of understanding regarding differential requirements for pain recognition and alleviation in male versus female animals.
Charles River is committed to eliminating sex bias in preclinical research and animal overproduction.
WEBINAR
From Bias to Balance: Addressing Sex Bias in Preclinical Research
Sex bias in research affects scientific outcomes, animal welfare, and public trust. Gain expert insights to help improve research outcomes and wellbeing for animals and society. Watch Now
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