Developmental and Reproductive Toxicology (DART) Studies
You can conduct your product safety assessment studies with confidence and compliance with internally recognized guidelines (ICH and OECD) using our comprehensive developmental and reproductive toxicology (DART) program planning and individual study design. In addition, we perform a range of specialized functional evaluations, including neurobehavioral testing and immunologic assays.
To date, we have commenced more than 100 of these complex DART studies. We also maintain an extensive Historical Control Data library which is fully available to you.
WEBINAR SERIES
Advance Your DART Programs with New Approach Methodologies (NAMs)
Join us for a two-part webinar series that will explore how chemical companies can strategically integrate NAMs and in vitro methods into testing and development workflows. Learn More
Our expertise spans across pharmaceuticals (including vaccines, biopharmaceuticals, and veterinary and medical devices) agrochemicals, industrial chemicals, and food additives.
A full range of rodent and nonrodent species are tested with dose routes ranging from dermal to intravenous infusion. A variety of specialized functional evaluations is also available including neurobehavioral testing and immunologic assays. All developmental and reproductive toxicity studies are supported by our own laboratory and regulatory experts.
DART Studies
- Specialized neurobehavioral testing
- Functional assessments, including growth (and the skeleton), pulmonary, neurobehavioral, reproductive, and immunological development
- Toxicokinetic evaluations, including induction studies
- Juvenile toxicity testing in rodents and nonrodent species
- Screening Information Data Sets (SIDS)
- Extended One Generation Reproductive Toxicity Study (EOGRTS)
Specialized Evaluations
- Hormone assays
- Male reproductive assessments in rodents and nonrodents
- Variety of behavioral tests (e.g., activity and learning and memory) for pre- and postnatal and multigenerational studies
- Range of developmental immunology tests that can be added to pre- and postnatal and multigenerational studies
- Endocrine disruptor screenings (in vivo and in vitro)
- Skeletal measurements (e.g., bone size, geometry, and density) for pre- and postnatal studies using micro-CT, pQCT, X-ray, and DXA
- Genomics
Developmental and Reproductive Pathology
Offering comprehensive laboratory pathology services of reproductive tissues, our staff is skilled in the detection of adverse effects of test articles and agents on reproduction and fertility.
Services
- Multispecies, fully automated sperm analysis
- Evaluation of male reproductive toxicity endpoints
- Maternal toxicity
- Fetal morphological examinations with mobile computer data system
- Soft tissue examinations
- Skeletal staining and evaluation
- Sperm/oestrous cycle analyses
- Neuro-histomorphometry
To perform these services and support you in your developmental and reproductive toxicity testing, we have a first-class professional pathology staff with more than 50 years of cumulative experience available.
Charles River's REACH eGuide
Our REACH eGuide helps you understand requirements, avoid common pitfalls, and develop an effective strategy to register your chemicals.
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Representative Juvenile and DART Studies Posters for Review
Explore these posters to learn what our scientists have been working on in the areas of DART studies, reproductive toxicity, juvenile toxicology, development toxicology studies, and more: