Tolerance, Safety, and Metabolism Studies
Charles River performs ADME, pharmacokinetic, bioequivalence, residue depletion, and target animal safety studies in compliance with EU, VICH, US, and Japanese regulations.
We have experience in formulating doses ranging from aquatic-based solutions to oil-based suspensions. Our modern facilities offer housing capacity for over 200 lactating cattle. Charles River also offers an integrated analytical service for clinical pathology, residue analysis, and metabolite profiling and identification. Our expert scientists are specialized in the design of target animal safety studies to satisfy the requirements of the various authorities in Europe, the US, and Japan.
Veterinary Pharmaceutical Development
From inception to registration: this interactive tool helps you to build a veterinary pharmaceutical program outline and obtain a ballpark price.
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Tolerance Testing in Target Animal Species
Our experts can design tolerance studies in target animal species to meet specific requirements for regulatory submissions. Flexibility in protocols allows us to pay special attention to the in-life use of the product with careful selection of dose levels and animal group sizes.
Target Animal Species
- Cattle
- Sheep
- Goat
- Pig (including neonatal)
- Poultry
- Marine and freshwater fish
Routes of Administration
- Topical and dermal
- Oral (dietary, capsule, or gavage)
- Intravenous
- Intraperitoneal
- Intramuscular
- Subcutaneous