Tumor Microarrays

Defined Tumor Tissue Microarray Plates to Support Model Selection

Containing >700 tumor models grouped by tumor entity, our current, sixth generation of tumor microarray allows us to individually screen cancer types by selecting from:

• Nine individual patient-derived (PDX) tumor plates (548 models)
• Two cell-line derived (CDX) tumor plates (100 models)
• Complemented by stand-alone brain tumor PDX plate (56 models) launched in January 2023
• One syngeneic tumor plate (32 models)

Syngeneic Model Data
Access our new syngeneic model data including checkpoint inhibitor (e.g. anti-PDL-1, anti-PD-1, anti-CTLA-4), whole exome sequencing (WES), and RNA-seq data. This data gives you the ability to choose based on mutation status in addition to sensitivity immune checkpoint inhibitors.
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Tissue microarray immunohistochemistry (IHC) is most commonly used for identification and confirmation of suitable tumor models by means of target protein expression (Figure 1). Charles River has a range of established antibody staining protocols to visualize key oncology targets, and we can also support development of novel targets.

Alternatively, you can receive our tumor microarrays slides to run your established assays yourself.

Figure 1. Tissue microarray immunohistochemical staining of tumor microarray plate containing various cancer types (anal, gastric, head and neck, esophageal, liver) to identify HER2-expressing tumor models. GXA 3039 and GXA 3040 are shown as examples for highly expressing and non-expressing tumor models, respectively, alongside the corresponding isotype control staining. Scale bares: 5 µM.

Each tumor model is represented by two individual biopsy cores of 1 mm diameter, sampled from representative regions of the grafted tumor, and arranged side by side on the microarray plates. A Hematoxylin and Eosin (H&E) counterstained digital slide of an early section from each TMA part is available on request as part of our service and allows assessment of the general histology of the biopsies. Upon identification of suitable tumor models by tumor tissue microarray screening on biopsy level, additional analyses can be performed on whole tumor sections for individual models to gain further insights.

Identify the Most Relevant Tumor Microarray for Your Project

Charles River offers a variety of tumor tissue microarray plates to help you select the most appropriate tumor model before proceeding to in vivo tumor models.