How CD34+ Humanized Mice Advance Your Research Program
As an essential tool for immuno-oncology and drug development studies, the CD34+ humanized mouse model provides a robust platform for studying human immune function. By engrafting immunodeficient mice with hematopoietic stem cells (HSCs), researchers can now investigate disease progression, immune interactions, and T cell development. With the ability to support long-term engraftment, the CD34+ humanized model bridges the gap between preclinical testing and clinical application.
When looking for study flexibility, humanized mice mouse models – including the CD34+ model – allow for custom humanization and tailored study design. This is best suited for studies on tumor biology, immuno-oncology, infectious diseases, graft-versus-host disease (GvHD), hematopoiesis, and tissue transplantation.
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Severely immunodeficient mice are preconditioned by whole-body irradiation, followed by intravenous engraftment of human CD34+ cells. Humanized mice carrying human CD45+ cells, including B- and T cells are ready for study 14-16 weeks post CD34+ cells engraftment.
What Are the Benefits of HuCD34+ NCG Humanized Mice?
| Convenient | These study-ready humanized mice provide a stable human immune system for extended studies. |
| Consistent | Every mouse is pre-tested for humanization, displays a robust T cell population, and offers high translational relevance. |
| Stable | Human CD34+ cells engraft stably. Engraftment of hematopoietic cells provides a research platform for extended studies. |
| Versatile | These models are flexible. Applications include cancer, infectious disease, drug development, and gene therapy studies. Multi-lineage engraftment is possible. |
| License-free | No additional licensing fees or royalty payments. |
Frequently Asked Questions (FAQs) About CD34+ Humanized Mice
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What is a CD34+ humanized mouse model?
The CD34+ humanized mouse model is an immunodeficient mouse engrafted with human CD34+ hematopoietic stem cells (HSCs).
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What is the role of the hematopoietic stem cells (HSCs) in a CD34+ humanized mouse?
HSCs allow the CD34+ humanized mouse model to develop a human-like immune system for preclinical research.
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How can I order the HuCD34+ NCG mouse from Charles River?
You can order HuCD34+ NCG mice by visiting our online ordering platform or contacting [email protected].
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What research applications should I use the HuCD34+ NCG mouse for?
The HuCD34+ NCG mouse model is widely used for research in immuno-oncology, infectious diseases, gene therapy, autoimmune diseases, and drug development.
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What is the source of the HSCs used in the HuCD34+ NCG mouse?
Human CD34+ stem cells are isolated from donor-consented, non-embryonic umbilical cord blood.
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Why are CD34+ humanized mouse models so often used in immune-oncology research?
CD34+ humanized mouse models provide a functional human immune system within a living organism through the development of human T cells, B cells, monocytes, and antigen-presenting cells. This allows researchers to study tumor immunity and therapeutic interventions.
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What are the biggest advantages to using CD34+ humanized mouse models?
The biggest advantages of using CD34+ humanized mouse models include human immune responses, long-term engraftment, and predictive preclinical drug evaluations.
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Are HuCD34+ NCG mice suitable for long-term studies?
Yes, the HuCD34+ NCG mouse model is designed to support long-term studies lasting up to several months.
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Do I need a license to use the HuCD34+ NCG mouse model for my research?
No, you do not need a license to use HuCD34+ NCG humanized mice for your research.