Fastest Contamination Detection with our ATP Reagents

ATP-bioluminescence, a gold standard rapid detection method, provides an effective approach to confidently detect the presence of microbial contamination in a sample. However, it is dependent upon microbial growth to achieve sufficient levels of ATP for detection. Celsis AMPiScreen® ATP assay kits include reagents that utilize a method of amplifying ATP that is not constrained by the finite amount of metabolic ATP available in the standard bioluminescence assay. The amplification of ATP beyond that which is inherent in the test sample is accomplished through a proprietary reagent, Celsis LuminAMP®, and an additional instrument-controlled amplification period to optimize the detection of microorganisms. 

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Gain insight into Celsis® technologies, platform capabilities, implementation considerations, validation support, and microbial detection applications across a range of product types.
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Sterility in 6 Days, Bioburden in 24 Hours 

Celsis AMPiScreen products amplify low levels of microbial ATP in a test sample to facilitate detection in Celsis® instruments. This naturally occurring reaction, which also provides the characteristic glow of fireflies, occurs when the luciferase enzyme converts luciferin into oxyluciferin to produce bioluminescence. This reaction requires the presence of ATP to occur.  

Ready-to-Use ATP Reagents For Rapid Detection 

Our Celsis AMPiScreen ATP assay kit is comprised of three separate ATP reagents, Celsis LuminAMP®, Celsis Luminex®, and Celsis LuminATE®. Each reagent is  ready to use off-the-shelf, except for a simple rehydration step of Celsis LuminATE with its included buffer. Reagents are then loaded into the easy access reagent holders on Celsis luminometers. 

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Regulatory Changes: USP 73 & 1071 Updates at a Glance
The latest chapters of USP <73> and <1071> introduce key updates impacting sterility testing and rapid microbiological methods (RMMs). Understanding these changes is crucial for compliance and optimizing your microbial testing strategy. Our expert guide breaks down what’s new and how Celsis® can help you stay compliant and efficient.
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