Explore Our SOLVO Transporter Cell Lines and Kits

Ready-to-use transporter products offer a convenient solution for researchers who wish to keep some of their ADME work in-house, eliminating the need for setting up each assay individually. Systems for addressing substrate and inhibition with the main human efflux (ABC) and uptake (SLC) transporters involved in drug-drug interactions are available as plated cells or cryopreserved in vitro models (membrane preparations and cells). A selection of additional transporters and preclinical orthologs are also offered depending on the assay system.

Frozen products are stored at ultralow temperature upon receipt and can be thawed anytime an experiment is planned. Cells can be seeded or membranes aliquoted into any appropriate plate format, customizable to your assay setup. Plated cells are delivered assay-ready for use immediately upon receipt.

3D illustration of a cell membrane lipid bilayer with transmembrane transporter molecule moving its substrates across.
SOLVO Membrane Transporter Products Catalog
Achieve faster, more reliable DMPK insights in the comfort of your own lab with SOLVO’s ready‑to‑use transporter products, spanning key efflux and uptake systems – all backed by rigorous quality control for reproducible, high‑confidence data.
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For all SOLVO products, rigorous quality control ensures reproducible assay performance: each batch undergoes testing for viability and transporter activity.

For outsourced drug transporter interaction studies, visit SOLVO drug transporter assays.

Product Types

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Cellular Permeability and Efflux (ABC) Transporter Products

CacoReady™: a ready-to-use Caco-2 assay system

Gloved hands of a scientist pipetting culture medium on a TransWell cell culture plate typically used in efflux (ABC) transporter interaction and permeability experiments. CacoReady kits are ready-to-use products with a freshly grown polarized monolayer of Caco-2 cells on a semi-permeable filter. The Caco-2 monolayer system is most commonly used for in vitro preclinical evaluation of oral dosage products. The cells in the CacoReady system form tight junctions, microvilli, and express transmembrane efflux transporters such as BCRP, MDR1, and MRP2, so are suitable for evaluation of (drug) molecules’ permeation through passive diffusion as well as active transport.

For a closer resemblance to the physiological intestinal structure, CacoGoblet™ was developed based on the same cellular monolayer principle, consisting of Caco-2 cells but co-cultured with functional goblet cells. This system, that also produces a mucus layer, allows for in vitro assessment of any potential modulations of permeability in an in vivo-like intestinal system.

PreadyPort™ : Monolayer-based Efflux Assessment Assay Kits

PreadyPort kits are ready-to-use products with a freshly grown polarized monolayer of transfected cells overexpressing the transporter of interest (or control cells) on a semi-permeable filter. The system is suitable for both efflux inhibition assays or for investigation of time- and concentration-dependent permeability of small molecules (substrate assessment). Active transport is determined based on bidirectional transport and calculation of an efflux ratio (basolateral-to-apical/apical-to-basolateral).

  • Cell line and transporter availability
    • CacoReady
      • Caco-2 cells
      • 24- or 96-well plate formats
    • CacoGoblet
      • co-culture of Caco-2 with goblet cells
      • 24-well plates
    • PreadyPort kits
      • Human BCRP and MDR1
      • MDCKII cellular background
      • MDCKII control cells available
      • 24- or 96-well plates
  • Shipping conditions
    • CacoReady, CacoGoblet, and PreadyPort plates are made to order and use a specific transportation medium to make sure cells are delivered in a ready-to-use condition. All plates are dispatched from the EU.
    • For PreadyPort plates, custom plating setups for transfected and control cells on a single plate are available on demand.

Membrane-based efflux (ABC) transporter products

Membrane Preparations for Traditional Vesicular Transport Assays

Tip of a pipette shown adding clear liquid onto a 96-well assay plate. The Traditional Vesicular Transport (VT) Assay is an effective tool for studying inhibition (IC50 or Ki value determination) as well as substrate identification for efflux transporters with low permeability test compounds.

The assay utilizes inside-out membrane vesicles produced from cells overexpressing the efflux transporter of interest. The assay is used to study accumulation in vesicles in the presence (active transport) and absence (control conditions) of ATP, the driving force of transport. Transporter-free negative control membranes are also available.

PrediVez™ Reagent Kits for inhibition assessment (IC50 determination)

PrediVez Reagent Kits are suitable for vesicular transport inhibition assays. The reagent kits contain a fluorescent probe substrate for the given transporter and the additional reagents needed. Kits are to be used with Traditional VT Membranes (purchased separately) and are available for the below listed membrane products.

PredEasy™ ATPase Assay Kits

Our SOLVO PredEasy ATPase Assay Kit is a unique product for measuring the ATPase-dependent drug-membrane ABC transporter interaction in a convenient, "ready-to-assay" package. The PredEasy kit delivers major technical improvements over the conventional ATPase assay, including higher sensitivity and shorter incubation times, and is an excellent choice for HTS assays.

PredEasy Kits contain membranes and all reagents (chemicals) and solutions necessary to conduct ATPase activation and inhibition assays, as well as all documentation needed for data evaluation and interpretation.

  • Cell line and transporter availability
    • Membrane preparations for VT assays
      • Human transporters: BCRP, BCEP, MDR1, MRP1, MRP2, MRP3, MRP4, MRP5
      • Rodent transporters: mBcrp, mBsep, mMdr1a, rBcrp, rBsep, rMdr1b, rMrp2, rMrp3
      • Other preclinical: dBsep, cyBcrp, cyBsep, cyMdr1
      • All human transporters expressed in a HEK293 cellular background, preclinical species transporters expressed in a HEK293 cellular background except for mBcrp, mBSEP, and rMdr1b
      • Certain transporters are available in other cellular backgrounds as well. For further information, please contact us.
    • Specific PrediVez reagent kits available for use with
      • Human BCRP, MDR1, MRP2, MRP3, or MRP5 VT membranes
    • PredEasy ATPase Assay Kits available for testing
      • Human MDR1 and MRP2
      • Rodent mBsep and rMdr1b
      • Transporters expressed in Sf9 or Sf9-HAM background
      • For 3 or for 10 assay plates (96-well format), with custom size kits available upon request
  • Shipping conditions
    • Membrane products are shipped and stored frozen at least at -80° C, allowing for flexible use. Dry-ice shipment is the default shipping method. Optionally, liquid nitrogen shipment is possible, but usually not required.
    • All products are shipped from the EU, but a selection of the most popular membrane preparations are also delivered via direct domestic shipment from our US warehouse.
    • Upon receipt, vesicles are recommended to be stored at -80° C.

Cellular uptake (SLC) transporter systems

TranSelect™

iStock-172640159.jpg Packaged in a convenient thaw-and-use format, SOLVO TranSelect kits enable your lab to study uptake – solute carrier (SLC) transporters. TranSelect cells can be seeded into any preferred plate format and used for transport inhibition assessment or for measuring the intracellular accumulation of a compound (substrate assay). In addition to the transfected uptake (SLC) transporter overexpressing cells, control cells are also available, and each order includes the appropriate amount of TranSelect™ Supplement for your assays. Cells are shipped from an EU warehouse within the EU and domestically within the US to your lab and can be subsequently stored frozen at ultralow temperature (in liquid nitrogen), allowing for flexible experiment design and timing.

Gloved hands of a scientist are holding up a 96-well assay plate typically used in uptake SLC transporter interaction assessment experiments.

Learn more about TranSelect
The TranSelect datasheet details the experimental principle and use cases and provides information on assay performance and product availability.
Read it Now

  • Cell line and transporter availability
    • TranSelect
      • Human transporters: MATE1, MATE2-K, OAT1, OAT3, OATP1B1, OATP1B3, OCT1, OCT2
      • HEK293 cellular background
      • HEK293 control cells available
      • TranSelect Supplement provided with each order
  • Shipping conditions
    • TranSelect
      • Cells are shipped and stored frozen at least at -80° C, allowing for flexible use. Liquid Nitrogen is the preferred shipping method, but for rapid domestic shipments, dry ice shipment is possible.
      • All TranSelect products are available with direct domestic US shipment from our US warehouse and direct EU dispatch from the EU SOLVO site.

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