Single Mouse Study Format
The SMT format employs a single mouse per PDX model and treatment arm, thereby enabling a cost-effective investigation of in vivo efficacy in large panels of PDX models. The SMT format reliably identifies compounds that are strongly active (or inactive) across a panel of tumor models, and can be used to investigate the most promising candidate compounds, new indications or optimal drug combinations.
Oncology Preclinical Study Planning Toolkit
Take control of your efficacy study by getting instant access to study pricing, cancer model data, and connection to our oncology specialists, so that you feel supported on your oncology efficacy journey.
Find the Right Model
Single Mouse Trials
Figure 1: Diagram of the single mouse trial format
Possible applications include:
- Identification of a large number of compounds in diverse tumor populations
- Efficient and reliable identification of treatments with broad anti-tumor activity
- Identification of resistance mechanisms
- Strategic exploration of new drug combinations
- Comprehensive exploration of one histotype
- Screening of a particular molecular characteristic
- Expansion of clinical indications by exploring other tumor types
- Generation of data for biomarker analysis and identification
For answers to your specific study questions, get in touch.
Mouse Models for Rapid In Vivo Screening
Use study-ready strains to support fast, small-cohort decision-making. Access immunodeficient and humanized options.
Need help selecting the right model? Ask our experts or use our Model Evaluation Program to de‑risk your decision.